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first pass effect

  • 首渡效应：指口服药物在消化道吸收后，首先进入肝门静脉系统；部分药物在通过肠黏膜和肝脏时，可能被代谢失去活性，从而使进入循环的药量减少，药效降低。

专业释义英英释义

  • 首过效应

·2,447,543篇论文数据，部分数据来源于NoteExpress

First pass effect

  • abstract: The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall.

以上来源于: WordNet

双语例句

  • Objective: To explore the first-pass effect in Small intestine.

    目的：探讨小肠在首过效应中的作用。

    youdao

  • Because of a serious liver first-pass effect, the dosage forms of Naloxone Hydrochloride is mainly used on domestic and aboard clinical practice in the forms of injection and sublingual tablet.

    但由于该药肝脏首过效应严重，口服无效，目前国内外临床上供应用的盐酸纳洛酮的剂型为注射液和舌下片。

    youdao

  • The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of nimodipine (NMD).

    本文旨在寻找制备一个吸收良好、稳定性好、可避免尼莫地平强的首过效应的制剂。

    youdao

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